Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?5/30/2023 ![]() This Scientific Statement is a critical review of the evidence supporting these eligibility criteria. These eligibility criteria were developed for the original alteplase pilot studies and have been carried forward over the years. The American Heart Association/American Stroke Association (AHA/ASA) published a Scientific Statement that evaluated the science underlying eligibility criteria for alteplase (intravenous tissue plasminogen activator) in acute ischemic stroke.
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